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I've had this happen a few times. I'm not sure why it's trying to save in this location.
Failed to save file. Error: [Error 3] The system cannot find the path specified: u'c:\users\patric~1\appdata\local\temp\tmpjbwskn.opensesame_pool\.'
I had to make a folder in the path before the program would save again.
I have had fewer crashes with the new version so hopefully this doesn't happen anymore. The new version still has the issue of not accepting esc-q though. This discussion can be closed.