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Is it possible to run an E-prime file (.es2) with OpenSesame ?
This is not possible. If you want to use Opensesame, you need to create your experiment with OpenSesame (or at least with python). However, creating an experiment is rather simple once you understand the structure of OpenSesame.
Why don't you have a look at our beginner's tutorial and check whether you see a way of rewriting your experiment in Opensesame?
Hope this helped.